Penn Medicine Heart and Vascular Center

Mitral Valve Disease Program

Penn Medicine’s Mitral Valve Program is one of the largest, most experienced in the mid-Atlantic region. Our team of experts, including surgeons, cardiologists, imaging experts, and dedicated nurses, work together to diagnose, treat, and provide long-term monitoring for patients with both common and complex mitral valve diseases.

We are proud to perform a high volume of procedures each year, leading to the best possible outcomes for patients. Our program leads the way in new options for mitral valve replacement and repair, including minimally invasive transcatheter and robotic valve procedures that were developed and perfected at Penn, as well as open-heart surgical options. Your multidisciplinary care team will focus on what is most important: getting you back to the things you love.

What We Offer to Our Patients

• Prompt and coordinated clinical evaluation and testing

• Careful monitoring and evaluation, through the use of advanced imaging technologies, establishing the most effective treatments

• Some of the most experienced physicians in the country at treating mitral valve disease

• Coordination of care with your local physician, including updating on your care and progress

• Access to ongoing, state-of-the-art research and clinical trials aimed at improving treatment options for mitral valve disease

Penn Presbyterian Medical Center has been honored with the 2025 Mitral Valve Repair Reference Center Award from the Mitral Foundation recognizing excellence in mitral valve surgery. This designation reflects Penn Medicine's continued commitment to delivering outstanding outcomes in mitral valve repair, driven by a patient-centered approach and supported by evidence based clinical practices.

Center for Bicuspid Aortic Valve Diseases

The Center for Bicuspid Aortic Valve Diseases provides comprehensive and coordinated clinical evaluations and monitoring for patients with bicuspid aortic valve and associated aortic aneurysm disease. The team at Penn’s Center for Bicuspid Aortic Valve Diseases will carefully evaluate your clinical and imaging workup to determine an optimal treatment and surveillance plan for you.

Approximately 80% of patients require surgery to repair or replace the valve and part of the aorta. If you do require surgery, know that Penn is a national leading center for the most challenging heart valve cases, offering a variety of approaches not commonly available at other medical centers.

What We Offer to Our Patients

• Prompt and coordinated clinical evaluations and long term surveillance for bicuspid aortic valve disease (BAVD)

• Complex bicuspid aortic valve repair and root reconstruction procedures by surgeon experts

• Capacity to offer an appointment within two weeks with one of our specialists

• Coordination of care with your local physicians, including updates on your care and progress

• BAVD experts provide careful monitoring and evaluation, through the use of advanced imaging modalities, establishing the most effective treatment

• An invitation for your first-degree relatives to participate in the program due to the hereditary nature of BAVD with the availability of combined surgical and genetic visits

• Access to ongoing, state-of-the-art research specifically for BAVD patients and their families

Transcatehter Aortic Valve Replacement (TAVR)

The Hospital of the University of Pennsylvania (HUP) was one of 23 hospitals nationwide that participated in the FDA regulated clinical trial examining the use of TAVR as part of the PARTNER clinical trial. Penn Medicine has subsequently been involved in the following studies and clinical trials:

• The Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD)

• PARTNER 3 - Trial - The Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis

• The PARTNER II Trial: Placement of AoRTic TraNscathetER Valves - PII A

• The PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - PARTNER II - PARTNERII - S3 Intermediate

• The PARTNER II Trial: S3Icap

• PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - High Risk and Nested Registry 7

• PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - Nested Registry 3/Valve-in-Valve • The PARTNER II Trial: Placement of AoRTic TraNscathetER Valves - PII B

• The PARTNER 3 - AVIV Trial (P3-AVIV)

• Cerebral Protection in Transcatheter Aortic Valve Replacement